Computational & Functional Genomics and Systems Biology
The research in my lab is focused on the following aspects:
- Developing genomics and computational approaches for the identification of one-dimensional (1D) genomic regulatory elements and three-dimensional (3D) chromatin interactions from the various omics data through next generation sequencing (NGS) technologies such as ChIP-exo, ChIP-seq, MBDCap-seq, Epic-seq, DRIP-seq, TCC (Hi-C), RNA-seq and miRNA-seq;
- Functionally and mechanistically characterizing the roles of epigenetic marks in cancer development and progression using novel techniques such as siRNA, 3C/ChIP/RT-qPCR, Western Blotting, 3D-FISH and CRISPR/Cas9;
- Developing computational pipelines to aid molecular biomarker discovery and to examine the significance of identified gene signatures;
- Adapting/applying genome-wide omics-seq techniques in patient tissues to identify epigenetic-driven therapeutic targets and markers.
We are working on various cancer models such as breast, prostate, pancreatic cancers, and leukemia.